Myostatin, the cardiac chalone of insulin-like growth factor-1

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Myostatin, the cardiac chalone of insulin-like growth factor-1.

In the 1960s, Bullough introduced the concept of chalones, inhibitors of cell growth that provide a negative feedback mechanism to control the size of a specific tissue [1]. In a very elegant study in this issue, Shu et al. [2] demonstrate that myostatin represents a chalone of the insulin-like growth factor-1 (IGF-1) pathway in the heart. The IGF-1 signaling pathway, as summarized in Fig. 1A, ...

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Optimization and Construction of Human Insulin-like Growth Factor 1 Gene related to human health

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Insulin-like growth factor-1 mediates stretch-induced upregulation of myostatin expression in neonatal rat cardiomyocytes.

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ژورنال

عنوان ژورنال: Cardiovascular Research

سال: 2005

ISSN: 0008-6363

DOI: 10.1016/j.cardiores.2005.09.007